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131,003 results

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Page 1
Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.
Kuepfer L, Niederalt C, Wendl T, Schlender JF, Willmann S, Lippert J, Block M, Eissing T, Teutonico D. Kuepfer L, et al. CPT Pharmacometrics Syst Pharmacol. 2016 Oct;5(10):516-531. doi: 10.1002/psp4.12134. Epub 2016 Oct 19. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27653238 Free PMC article.
The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their practical implementation in a typical PBPK model building workflow. To illustrate basic …
The aim of this tutorial is to introduce the fundamental concepts of physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) mode …
Comparative Protein Structure Modeling Using MODELLER.
Webb B, Sali A. Webb B, et al. Curr Protoc Bioinformatics. 2016 Jun 20;54:5.6.1-5.6.37. doi: 10.1002/cpbi.3. Curr Protoc Bioinformatics. 2016. PMID: 27322406 Free PMC article.
The prediction process consists of fold assignment, target-template alignment, model building, and model evaluation. This unit describes how to calculate comparative models using the program MODELLER and how to use the ModBase database of such …
The prediction process consists of fold assignment, target-template alignment, model building, and model evaluation. Th …
Model Selection: Finding the Right Fit.
Jupiter DC. Jupiter DC. J Foot Ankle Surg. 2019 Mar;58(2):403-404. doi: 10.1053/j.jfas.2019.01.009. J Foot Ankle Surg. 2019. PMID: 30850106
There are numerous possible goals for building statistical models. Those statistical goals, the associated model types, and each statistical tool involved in model building come with its own assumptions and requirements. In turn, these requireme …
There are numerous possible goals for building statistical models. Those statistical goals, the associated model types, …
Chemometrics for Raman Spectroscopy Harmonization.
Barton B, Thomson J, Lozano Diz E, Portela R. Barton B, et al. Appl Spectrosc. 2022 Sep;76(9):1021-1041. doi: 10.1177/00037028221094070. Epub 2022 May 27. Appl Spectrosc. 2022. PMID: 35622984 Review.
However, regular validation is required to ensure that aging or incorrect maintenance of the instrument does not alter the model's predictions, particularly when applied in regulated fields such as pharmaceuticals. ...Important processing steps will be the calibrati …
However, regular validation is required to ensure that aging or incorrect maintenance of the instrument does not alter the model's …
Statistical considerations on prognostic models for glioma.
Molinaro AM, Wrensch MR, Jenkins RB, Eckel-Passow JE. Molinaro AM, et al. Neuro Oncol. 2016 May;18(5):609-23. doi: 10.1093/neuonc/nov255. Epub 2015 Dec 8. Neuro Oncol. 2016. PMID: 26657835 Free PMC article. Review.
Here, we review the statistical considerations of how to build and validate prognostic models, explain the models presented in the current glioma literature, and discuss advantages and disadvantages of each model. ...Via external validation, an indepen …
Here, we review the statistical considerations of how to build and validate prognostic models, explain the models prese …
How and why to build a mathematical model: A case study using prion aggregation.
Banwarth-Kuhn M, Sindi S. Banwarth-Kuhn M, et al. J Biol Chem. 2020 Apr 10;295(15):5022-5035. doi: 10.1074/jbc.REV119.009851. Epub 2020 Jan 31. J Biol Chem. 2020. PMID: 32005659 Free PMC article. Review.
However, developing useful mathematical models is challenging because of the often different domains of knowledge required in both math and biology. ...We close by discussing the many opportunities that abound for both experimentalists and modelers to take advantage …
However, developing useful mathematical models is challenging because of the often different domains of knowledge required in both ma …
Simulation-assisted machine learning.
Deist TM, Patti A, Wang Z, Krane D, Sorenson T, Craft D. Deist TM, et al. Bioinformatics. 2019 Oct 15;35(20):4072-4080. doi: 10.1093/bioinformatics/btz199. Bioinformatics. 2019. PMID: 30903692 Free PMC article.
MOTIVATION: In a predictive modeling setting, if sufficient details of the system behavior are known, one can build and use a simulation for making predictions. ...These similarity values, rather than the original high dimensional feature data, are used to build …
MOTIVATION: In a predictive modeling setting, if sufficient details of the system behavior are known, one can build and use a …
Prognostic models: What the statistician wants the clinician to know.
Allen E, Robb ML. Allen E, et al. Best Pract Res Clin Gastroenterol. 2023 Dec;67:101872. doi: 10.1016/j.bpg.2023.101872. Epub 2023 Oct 9. Best Pract Res Clin Gastroenterol. 2023. PMID: 38103928 Review.
Prognostic model building is a process that begins much earlier than data analysis and ends later than when a model is reached. It requires careful delineation of a clinical question, methodical planning of the approach and attentive exploration of the data b …
Prognostic model building is a process that begins much earlier than data analysis and ends later than when a model is …
ModelBricks-modules for reproducible modeling improving model annotation and provenance.
Cowan AE, Mendes P, Blinov ML. Cowan AE, et al. NPJ Syst Biol Appl. 2019 Oct 8;5:37. doi: 10.1038/s41540-019-0114-3. eCollection 2019. NPJ Syst Biol Appl. 2019. PMID: 31602314 Free PMC article. Review.
Most computational models in biology are built and intended for "single-use"; the lack of appropriate annotation creates models where the assumptions are unknown, and model elements are not uniquely identified. ...It is akin to building a brick house s …
Most computational models in biology are built and intended for "single-use"; the lack of appropriate annotation creates models …
Comprehensive evaluation of an advanced street canyon air pollution model.
Hood C, Stocker J, Seaton M, Johnson K, O'Neill J, Thorne L, Carruthers D. Hood C, et al. J Air Waste Manag Assoc. 2021 Feb;71(2):247-267. doi: 10.1080/10962247.2020.1803158. J Air Waste Manag Assoc. 2021. PMID: 32735484
Comparisons have been made between modeling using the new canyon model; a simpler approach to canyon modeling based on the OSPM formulation; and without any inclusion of canyon effects. The TRAPOS dataset has been used to highlight the model's a …
Comparisons have been made between modeling using the new canyon model; a simpler approach to canyon modeling based on …
131,003 results
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